منابع مشابه
Mol090985 735..746
At concentrations that produce anesthesia, many barbituric acid derivatives act as positive allosteric modulators of inhibitory GABAA receptors (GABAARs) and inhibitors of excitatory nicotinic acetylcholine receptors (nAChRs). Recent research on [H]R-mTFD-MPAB ([H]R-5-allyl-1-methyl-5-(m-trifluoromethyldiazirinylphenyl)barbituric acid), a photoreactive barbiturate that is a potent and stereosel...
متن کاملMol083352 746..752
The function of many ion channels is under dynamic control by coincident activation of G-protein-coupled receptors (GPCRs), particularly those coupled to the Gas and Gaq family members. Such regulation is typically dependent on the subunit composition of the ionotropic receptor or channel as well as the GPCR subtype and the cell-specific panoply of signaling pathways available. Because GPCRs an...
متن کاملMol099341 746..757
Upon treatment with the pregnane X receptor (PXR) activator rifampicin (RIF), human hepatocellular carcinomaHepG2-derived ShP51 cells that stably express PXR showed epithelialmesenchymal transition (EMT)–like morphological changes and migration. Our recent DNA microarrays have identified hepatocyte nuclear factor (HNF) 4a and insulin-like growth factorbinding protein (IGFBP) 1 mRNAs to be downr...
متن کاملAjcn27462i 743..746
L-Glutamate confers cognitive discrimination for umami taste (delicious or savory) and dietary information to the brain through the activation of G protein–coupled receptors in specialized taste receptor cells of the tongue. The taste heterologous receptor T1R1 plus T1R3 is not sufficient to detect umami taste in mice. The lack of T1R3 diminished but did not abolish nerve and behavioral respons...
متن کاملResume Ed 389 746 Tm 024 379
Some applications of Bayesian decision theory to intelligent tutoring systems are considered. How the problem of adapting the appropriate amount of instruction to the changing nature of a student's capabilities during the learning process can be situated in the general framework of Bayesian decision theory is discussed in the context of the Minnesota Adaptive Instructional System (MAIS) . Two b...
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ژورنال
عنوان ژورنال: Mnemosyne
سال: 2023
ISSN: ['0026-7074', '1568-525X']
DOI: https://doi.org/10.1163/1568525x-bja10208